Natural Ambroxane
Ambroxene naturally occurring autoxidation or photooxide of the triterpenoid secreted by sperm whales.
Industrially, ambroxide can be prepared from nerolidol via oxidation to a homofarnesic-acid-type intermediate, followed by acid-catalysed cyclisation to afford ambroxide.
Ambroxide is commercially available in stereochemically distinct forms, including the naturally occurring (−)-enantiomer (CAS 6790-58-5, this product) and the racemic material (CAS 3738-00-9, often marketed as Cetalox). The (−)-enantiomer is often described as having a warmer, more diffusive ambergris profile with an exceptionally low odour threshold, while the racemate is typically perceived as drier and somewhat smokier or leathery.
Substance Identification
| Synonyms | Ambrox | Ambroxide |
| CAS | 6790-58-5 |
| EINECS | 229-861-2 |
| FEMA | 3471 |
| HS.CODE | 2932.99 |
| Molecular Formula | C16H28O |
| Molecular Weight | 236.39 |
Application & Uses
- Mainly used for tabacco, it is harmonized with the characteristic wood flavor of tobacco, and can cover up miscellaneous gas, and also can improve the aroma quality of tobacco. It is especially suitable for adding fragrance to blended cigarettes and enhancing the flavor of Oriental tobacco.
- Applied to fragrant of raspberry, blackberry and tea flavor, is all kinds of high-end fragrance fixing agent
Features & Benefits
Sales Specification
| ITEM | VALUE |
|---|---|
| Appearance | White crystals |
| Odor | Natural whale amber. sweet, woody |
| Assay, @GC, % | 99 min |
Q&A
What specification parameters should a procurement team prioritise when sourcing ambroxide for tobacco flavouring applications?
For tobacco flavouring, the first thing to check is whether the identity matches what you need. If you want the natural single enantiomer, that means CAS 6790-58-5; if you need the racemate, it is CAS 3738-00-9. That matters more than EINECS or FEMA numbers, because the two forms are not identical in odour profile or end-use positioning. Once identity is confirmed, the main checks are 99%+ GC assay and a white crystal appearance: higher purity helps keep trace impurities from showing up as off-notes, while yellowing usually means the material or storage conditions should be reviewed. For procurement, the real focus should be enantiomer, purity and batch consistency.
When should a formulator consider ambroxide for pet care fragrance applications, and what properties distinguish it from general-purpose fixatives?
Ambroxide is better treated as a low-dose base-note modifier rather than a default fragrance choice for pet-care products. Its 99% GC assay helps reduce impurity-related off-notes, which is useful in pet-care formulations where a clean, restrained scent profile is preferred. For dogs in particular, the real issue is exposure level and persistence of scent, because canine olfaction is extremely sensitive and even fragrances that seem mild to humans can become uncomfortable in small spaces, with prolonged exposure or direct coat contact. We did not find a published, universal ppm limit for ambroxide in pet-care products; if it is used at all, it should be handled as an ultra-low-dose fragrance material, with pet-acceptance testing and restrained longevity rather than strong substantivity.
How can ambroxide be positioned as an ambergris-style fixative option as fragrance companies look for alternatives to persistent polycyclic musks under tighter environmental scrutiny?
Under tighter environmental scrutiny, ambroxide is better positioned as an ambergris-style fixative choice rather than a direct regulatory replacement for polycyclic musks. Musks such as HHCB and AHTN have drawn long-term attention because of their environmental persistence, limited removal in wastewater treatment, and retention in sludge and sediment, which is exactly the kind of profile the REACH PBT/vPvB framework is designed to assess. Ambroxide, by contrast, offers a clean, stable ambergris-like woody base note that supports longevity, diffusion and overall fragrance structure, and the 99% GC assay plus clearly defined identity on the Foreverest page help maintain lot-to-lot consistency. That said, calling it a "greener" substitute still depends on the actual environmental fate data, the regulatory context, and the total exposure level in the finished formula, rather than on natural origin or FEMA GRAS status alone.
GHS Hazard Statements
| Not classified |
Storage
- ground all equipment containing material
- keep away from heat
- keep away from sources of ignition
- keep container tightly closed
- keep in a cool, well-ventilated place
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The above information is believed to be accurate and represents the best explanation currently available to us. However, no liability is assumed for any consequences arising from the use of this content. The technical standards for our products are developed and updated jointly by our customers and ourselves; where any changes occur, the latest specification shall prevail and will be confirmed in the relevant contract.All suggestions and data provided are based on information we consider to be reliable and are offered in good faith, but without any guarantee, as the conditions and methods of use of our products are beyond our control. Foreverest® makes no warranties, whether express or implied, regarding the accuracy, completeness or suitability of this information, and expressly disclaims any implied warranty of fitness for a particular purpose. Prospective users should conduct their own tests and evaluations to determine the suitability of Foreverest® materials and any recommendations for their intended applications before adoption, and, where appropriate, should obtain confirmation or approval from the relevant regulatory authorities.Any references in this page to patents or patented technologies, including descriptive material derived from patents or citations of specific patent numbers, are provided for information only. They must not be interpreted as a recommendation to use our products in a manner that could infringe any third‑party patent, nor as a grant of any licence or permission to use patents owned by Foreverest®.
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