Nerolidol
Nerolidol, also known as peruviol or penetrol, is a naturally occurring sesquiterpene. It is found in various essential oils, including neroli, petitgrain oil, cananga oil, and jasmine oil. Nerolidol appears as a colourless to pale yellow clear oily liquid with a distinctive minty floral odour. Its purity is typically 90% minimum.
Nerolidol is industrially prepared using linalool as the raw material, which is converted into geranyl acetone, followed by ethynylation and hydrogenation reactions.
Substance Identification
| Synonyms | trans-Nerolidol | Peruviol | Melaleucol | Methyl vinyl homogeranyl carbinol | Methylvinylhomogeranyl carbinol |
| CAS | 7212-44-4 |
| EINECS | 230-597-5 |
| FEMA | 2772 |
| HS.CODE | 290500 |
| Molecular Formula | C15H26O |
| Moleclar Weight | 222.372 |
Toxicological Information
| LD50 oral, rat | 5gm/kg min |
| LD50 dermal, rabbit | 5gm/kg min |
Application & Uses
- Fragrance & Flavour:
- Primarily used in the fragrance formulation of high-quality cosmetics, and also in the flavouring of food and beverages. For instance, a small addition of 0.05% is effective for ready-to-drink beverages or simple broths.
- Pharmaceutical & Bioactivity:
- Serves as an important intermediate in the synthesis of vitamin E.
- Exhibits anti-fungal, antimicrobial, and sedative properties.
- Possesses anti-leishmaniasis and anti-malarial properties.
- Studies indicate its potential anti-ulcer, anti-cancer, and anti-tumour activity.
- Demonstrates insect repellent activity.
- Functions as a skin penetration enhancer.
- Displays anti-nociceptive and anti-inflammatory effects.
- Exhibits anti-parasitic and anti-biofilm properties.
- Shows antioxidant activity.
Features & Benefits
Nerolidol imparts a subtle, delicate floral fragrance that is generally pleasant and not overpowering. Its floral notes primarily include lavender, lily, and cedar, with dominant nuances reminiscent of lily of the valley. Despite its delicate nature, Nerolidol possesses a high concentration of aroma and a broad spectrum of effects. It is well-suited for enhancing a variety of more volatile fragrances, capable of increasing their depth and richness, thereby helping perfumers unlock their intrinsic flavouring properties.
Sales Specification
| ITEM | VALUE |
|---|---|
| Appearance | Colorless to pale yellow clear oily liquid |
| Specific Gravity, @25.00 °C | 0.87000 to 0.87600 |
| Refractive Index, @20.00 °C | 1.47800 to 1.48300 |
| Optical Rotation, ° | -2.00 to +2.00 |
| Purity, % | 90 min |
| LD50 oral, rat | 5gm/kg min |
| LD50 dermal, rabbit | 5gm/kg min |
GHS Hazard Statements
| H-Code | H317/319/410 |
| P-Code | P261/264/272/273/280 |
| Response | P302+P352 P305+P351+P338 P333+P313 P337+P313 P391 |
| Storage | No data available |
| Disposal | P501 |
Storage
- Environmental & Temperature Control:
- Store in a cool, dry, well-ventilated area, and protect from light.
- Avoid high temperatures to maintain product stability and prevent decomposition or volatilisation.
- Keep in a cool, well-ventilated place.
- Container Management & Prevention:
- Ensure containers are tightly closed to prevent volatilisation and external contamination, and are clearly labelled.
- Ground all equipment containing the material to prevent static build-up.
- Hazard Isolation:
- Keep storage areas away from heat, sparks, open flames, and all sources of ignition.
- This combustible liquid should be stored in a separate safety storage cabinet or room.
- Keep away from incompatible materials to prevent hazardous reactions.
- Safe Handling & Inspection:
- Handle carefully, and stack stably.
- After prolonged storage, always check quality before use.
- Compliance & Emergency Preparedness:
- Strictly comply with all safety regulations, particularly those pertaining to combustible liquid storage.
- Ensure emergency plans are in place for unforeseen circumstances.
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The above information is believed to be accurate and presents the best explanation currently available to us. We assume no liability resulting from above content. The technical standards are formulated and revised by customers’ requirement and us, if there are any changes, the latest specification will be executed and confirmed in the contract.
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