WS Series Cooling Agent Procurement Guide

• GENU® Gum Type RL-200 from Azelis®, formulated with WS-5, is a highly refined locust bean gum standardised with sucrose that delivers a refreshing, non-irritating cooling sensation—free from any stinging or sharpness. By combining WS-5 with this premium gum base, the formulation enhances mouthfeel and texture in chewing gum without imparting unwanted flavours, offering a clean, long-lasting coolness most noticeable on the roof of the mouth and the back of the tongue. WS-5 provides approximately four times the cooling intensity of menthol, with effects lasting up to 10 minutes. Leveraging WS-5’s stability and GRAS status, the recommended usage level of 1,000–5,000 ppm enables an ice-fresh burst while maintaining the product’s structural integrity.
• P&G® Oil-in-Water Emulsion Toothpaste featuring WS-3 and WS-5 incorporates these cooling agents at concentrations ranging from 0.001% to 5%. WS-3 delivers an immediate, clean cooling sensation at the back of the mouth and tongue—approximately 1.5 times stronger than menthol and lasting around six minutes—while WS-5 amplifies the effect to about 2.5 times menthol’s intensity, offering prolonged freshness without any bitterness. Together, they enhance sensory perception in oral care, improving both emulsion stability and consumer appeal. Their high potency allows effective performance at low use levels (500–4,000 ppm in toothpaste), significantly reducing the need for volatile menthol while delivering a smooth, powerful cooling experience.

• Takasago® WS-3 and WS-5 are used in beverages at typical levels of 10–50 ppm (up to 5%) to deliver clean, non-irritating cooling—WS-3 offers an immediate effect (1.5× menthol strength, ~6 min duration), while WS-5 provides longer-lasting, more intense coolness (2.5× menthol) without bitterness or volatility. Ideal for fruit juices, teas, soft drinks, energy drinks, and alcoholic beverages, they enhance flavour clarity, simulate ice-cold refreshment, and improve emulsion stability. Effective at low doses (500–4,000 ppm), they reduce reliance on menthol, extend perceived freshness (up to 10 minutes post-consumption), and pair seamlessly with sugar alcohols like xylitol. As GRAS-approved ingredients, they enable great-tasting, low-sugar functional drinks with no off-notes—supporting vitality and consumer appeal.

• Givaudan®’s WS-3 (N-ethyl-p-menthane-3-carboxamide) is being explored as a dual-action mosquito repellent prototype, leveraging its cooling and insect-repellent properties. Lab studies by Gautschi and Blondeau show that WS-3 and related N-substituted p-menthane carboxamides repel cockroaches as effectively as—or better than—DEET, with comparable activity against Aedes mosquitoes via TRPM8-mediated sensory disruption. Applied at low concentrations (0.5–2%), WS-3 delivers immediate, non-irritating skin cooling—1.5 times stronger than menthol and lasting over six minutes—while forming an odour-based barrier without menthol’s volatility or bitterness. In spray lotions and similar prototypes (e.g., Givaudan® patent US20040028714), it enhances user compliance through a refreshing “sensory shield,” reducing reliance on DEET. As a natural-identical, GRAS-approved ingredient (FEMA 3455), WS-3 offers a skin-friendly solution that bridges cosmetic appeal and public health.

> Read more stories about the application of WS derivatives in mosquito repellents.