Cooling Agents WS-23

WS-23 (2-Isopropyl-N,2,3-trimethylbutanamide) is renowned for its clean and long-lasting cooling effect (with a cooling strength of approximately 0.75). Unlike menthol, WS-23 delivers a cooling sensation without any accompanying minty flavour or odour, making it highly versatile for a wide range of applications.

WS-23 has KOSHER ,HALAL,REACH ready.

Substance Identification

Synonyms 2-Isopropyl-N,2,3-trimethylbutanamide
CAS 51115-67-4
EINECS 256-974-4
FEMA 3804
HS.CODE 292429
Molecular Formula C10H21NO
Molecular Weight 171.28

Application & Uses

WS-23 is widely used across diverse product categories, including:
  • Oral care products (e.g., toothpaste, mouthwash)
  • Cosmetics (e.g., creams, lotions)
  • Food and beverages
  • Pharmaceuticals
  • Personal care items (e.g., shampoos, conditioners)
It serves as one of the most common cooling agents in high-intensity cooling candies, mouthwashes, and beverages, with typical addition levels of 0.3%–0.5%. Unlike menthol, which develops bitterness above 0.08%, WS-23 maintains a clean profile at these concentrations. Pulverising WS-23 breaks down its crystalline structure into finer, powder-like particles, making it easier to incorporate into compressed tablets. Most commercially available compressed lozenges and ring-shaped candies now rely on WS-23 as their primary cooling agent.

Features & Benefits

  • WS-23 exhibits excellent stability, making it ideal for formulations requiring consistent and prolonged cooling effects. It has virtually no odour or taste and low volatility, with a mild, refreshing mint flavour that delivers strong, impactful cooling which dissipates quickly (lasting approximately 7 minutes).
  • It is generally recognised as safe (GRAS) for use in food, cosmetics, and personal care products when applied within recommended concentrations.
  • Sparingly soluble in water at room temperature but highly soluble in hot water. Once dissolved in propylene glycol, it can be directly solubilised in water at ambient temperature and is readily soluble in alcohol and fats.
  • Slightly less intense than WS-3, yet smoother without side effects like burning, numbness, or irritation. Sensory evaluations confirm WS-23 provides a cooler sensation than menthol, primarily affecting the front of the tongue and mouth.
 
min max
Fog-fluid 450 ppm 2250 ppm
Beverage 3 ppm 24 ppm
Toothpaste 300 ppm 3000 ppm
Mouthwash 15 ppm 600 ppm
Hard candy 30 ppm 150 ppm
Chewing gum 1500 ppm 9000 ppm
Creams & Lotions 1500 ppm 15000 ppm
Recommended usage level WS-23

Sales Specification

ITEM VALUE TEST METHOD & UNIT
Cooling Strength 0.75 @Menthol was set as 1 as a reference
Cooling Longevity 8 minutes
ITEM VALUE TEST METHOD & UNIT
Cooling Strength 1.5 @Menthol was set as 1 as a reference
Cooling Longevity 6 minutes
ITEM VALUE TEST METHOD & UNIT
Cooling Strength 4 @Menthol was set as 1 as a reference
Cooling Longevity 10 minutes
ITEM VALUE TEST METHOD & UNIT
Cooling Strength 4.5 @Menthol was set as 1 as a reference
Cooling Longevity 12 minutes
ITEM VALUE TEST METHOD & UNIT
Cooling Strength 3.5 @Menthol was set as 1 as a reference
Cooling Longevity 36 minutes

Q&A

Can WS-23 be used in e-liquid formulations, and how does it perform in vaping products?

WS-23 is widely adopted in e-liquid formulations, with recommended usage levels of 450 to 2,250 ppm for fog-fluid applications. Its primary advantage in vaping is the absence of any minty flavour or odour, which allows the e-liquid's intended flavour profile to remain unaltered while delivering a clean cooling sensation concentrated at the front of the tongue and mouth. In practice, WS-23 is frequently blended with WS-3 in e-liquids to achieve a balanced effect — WS-23 provides an immediate, smooth front-of-mouth coolness while WS-3 contributes a deeper throat hit. Major e-cigarette manufacturers including Vaporesso, JUUL, and Puff Bar are identified as significant consumers of WS-series cooling agents.

Why would a formulator choose WS‑23 instead of menthol when designing products that require very high cooling intensity?

Menthol delivers a strong cooling effect but also brings a characteristic minty flavour and can introduce harsh or bitter notes as its concentration increases, which limits its use in products that require very high cooling intensity, especially in non-mint flavour systems. By contrast, WS‑23 provides a clean cooling sensation with minimal minty flavour or odour at typical use levels (often around 0.1–0.3% in foods and oral care products, and higher in applications such as e‑liquids), allowing formulators to achieve stronger cooling without unwanted bitterness or menthol off-notes. WS‑23 is also virtually odourless and tasteless, so it does not introduce minty notes that might clash with fruit, dairy, or other non-mint flavour profiles. In addition, WS‑23 exhibits lower volatility and better heat stability than menthol, which tends to evaporate or degrade more readily during processing and storage, helping WS‑23-based systems maintain more consistent cooling intensity over a product's shelf life.

How is WS-23 incorporated into compressed tablets and hard candies?

WS‑23 is supplied as a crystalline solid that can be milled into fine, free-flowing particles, which makes it easy to blend into standard tablet and candy premixes together with conventional excipients such as binders, fillers, and lubricants. In hard candies, typical recommended usage levels fall in the range of about 30 to 150 ppm, while chewing gum formulations often use higher levels, on the order of 1,500 to 9,000 ppm, depending on the desired cooling intensity and the presence of other cooling agents. Many modern compressed lozenges and ring-shaped candies now incorporate WS‑23 as one of their main cooling components, because its almost odourless profile allows fruit, herbal, or other flavour characters to remain the dominant sensory notes instead of being overwhelmed by a strong mint taste.

What solubility considerations apply when using WS-23 in water-based formulations?

WS‑23 is sparingly soluble in water at room temperature, but its solubility increases significantly in hot water, which can be used to aid dissolution when processing conditions allow. For ambient‑temperature manufacturing, a practical strategy is to first dissolve WS‑23 in propylene glycol to prepare a stock solution, which can then be directly dispersed or solubilised into the aqueous phase. WS‑23 is also readily soluble in ethanol and in oils or fats, providing additional formulation routes for oil‑based or ethanol‑containing systems such as flavoured beverages, oral care products, or cosmetic sprays. In beverages, typical recommended usage levels are in the range of about 3 to 24 ppm, while mouthwash formulations may range from roughly 15 to 600 ppm, with the exact concentration depending on the desired cooling intensity and the overall flavour and fragrance profile of the water‑based application.

Package

  • Customizable packaging details.

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GHS Hazard Statements

Storage

  • Flammable materials should be stored in a separate safety storage cabinet or room
  • Ground all equipment containing material
  • Keep away from heat
  • Keep away from sources of ignition
  • Keep container tightly closed
  • Keep in a cool, well-ventilated place

Relation Articles


Remark

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The above information is believed to be accurate and represents the best explanation currently available to us. However, no liability is assumed for any consequences arising from the use of this content. The technical standards for our products are developed and updated jointly by our customers and ourselves; where any changes occur, the latest specification shall prevail and will be confirmed in the relevant contract.All suggestions and data provided are based on information we consider to be reliable and are offered in good faith, but without any guarantee, as the conditions and methods of use of our products are beyond our control. Foreverest® makes no warranties, whether express or implied, regarding the accuracy, completeness or suitability of this information, and expressly disclaims any implied warranty of fitness for a particular purpose. Prospective users should conduct their own tests and evaluations to determine the suitability of Foreverest® materials and any recommendations for their intended applications before adoption, and, where appropriate, should obtain confirmation or approval from the relevant regulatory authorities.Any references in this page to patents or patented technologies, including descriptive material derived from patents or citations of specific patent numbers, are provided for information only. They must not be interpreted as a recommendation to use our products in a manner that could infringe any third‑party patent, nor as a grant of any licence or permission to use patents owned by Foreverest®.

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