Industry News Tracker | Personal Care Magazine | May 24, 2022 (Original Release Date)
Read Original Full Article at Personal Care Magazine

Executive Brief

A breakthrough in “Molecular Farming” has produced a sustainable, plant-based alternative to retinol that outperforms traditional synthetic options. French biotechnology company Core Biogenesis utilizes Camelina sativa (an oilseed crop) as a bio-factory to produce human-identical growth factors. These actives, stabilized by natural oil bodies (oleosomes), demonstrate superior stability and anti-aging efficacy in clinical trials without the irritation typically associated with retinol. This technology represents a significant shift towards “Green Biotechnology” in the personal care sector, offering a scalable, carbon-negative production method.

Technical Intelligence

1. Core Technology & Production

• Production Platform: Molecular Farming (Plant-based expression system).
• Host Organism: Camelina sativa (Non-food oilseed crop).
• Delivery System: Oleosome Technology. Growth factors are fused to the plant’s natural oil bodies (oleosomes), which act as a protective shield and delivery vehicle.
• Key Innovation: This fusion mimics the natural seed structure, protecting unstable proteins from degradation and enhancing skin penetration.

2. Active Ingredients Profile

• Peauvita™ (read original full product at corebiogenesis.com):
  • Composition: Oleosome-EGF (Epidermal Growth Factor).
  • Primary Function: Skin firmness, wrinkle reduction.
• Peauforia™
  • Composition: Oleosome-FGF-2 (Fibroblast Growth Factor 2).
  • Primary Function: Skin barrier restoration, hyperpigmentation reduction.
• Mechanism of Action: Activates natural cellular signaling pathways (unlike retinol which relies on controlled irritation to stimulate turnover).

3. Clinical Performance Data (vs. Retinol)

• Wrinkle Reduction (30 Days):
  • Peauvita/Peauforia Combo: -25.5% reduction in wrinkle depth.
  • Traditional Retinol: -16.3% reduction.
• Speed of Efficacy: Significant improvements in skin firmness and fine lines visible in 14 days.
• Stability: Actives are 8-10x more stable than traditional recombinant growth factors due to oleosome encapsulation.
• Safety Profile: Zero reported irritation (no redness, dryness, or peeling), making it suitable for sensitive skin.

4. Sustainability & Compliance

• Environmental Impact: High-yield production via photosynthesis reduces energy and water consumption compared to bacterial fermentation (bioreactors).
• Certifications: Vegan, Cruelty-free, GMO-free final product (purified proteins).
• Carbon Footprint: Scalable agricultural process with a significantly lower carbon footprint than chemical synthesis.

Entity & Keyword Index

Category	Entities / Keywords
Chemicals & Actives	Retinol Alternative, EGF (Epidermal Growth Factor), FGF-2 (Fibroblast Growth Factor), Oleosomes, Recombinant Proteins
Technologies	Molecular Farming, Plant Bio-factory, Transdermal Delivery, Biomimetic
Applications	Anti-aging Serums, Sensitive Skin Care, Clean Beauty, Vegan Skincare
Companies	Core Biogenesis (France), Personal Care Magazine (Source)

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